Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | STK17B | O94768 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24255306 | 0.92 | APP (0.50) | TP53MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL18488673 | 0.86 | APP (0.50) | CTSCHPGDPIK3CDPIK3R1STK17A | |
| SCHEMBL25669146 | 0.78 | STK17A (0.48) | STK17ASTK17BTLR8 | |
| SCHEMBL18487897 | 0.78 | CCND3 (0.41) | STK17ATP53STK17BMAPT | |
| SCHEMBL18488449 | 0.77 | HDAC3 (0.45) | STK17ASTK17BPOLBMAPT | |
| SCHEMBL29555879 | 0.77 | APP (0.60) | STK17ATP53STK17BMAPTCYP1A2 | |
| SCHEMBL18488360 | 0.77 | APP (0.60) | STK17ATP53STK17BMAPTCYP1A2 | |
| SCHEMBL17035558 | 0.76 | TLR8 (0.54) | TP53TLR8TLR7 | |
| SCHEMBL18488361 | 0.75 | CYP2D6 (0.49) | STK17ATP53STK17BMAPTTMIGD3 | |
| SCHEMBL18488325 | 0.74 | HDAC3 (0.40) | STK17ATP53STK17BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023899-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2017-02-09 | — | — | WO | disclosed |