Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.73 |
| ▸ | ALK | Q9UM73 | 14/20 | 0.66 |
| ▸ | INSR | P06213 | 8/20 | 0.66 |
| ▸ | IGF1R | P08069 | 7/20 | 0.66 |
| ▸ | EGFR | P00533 | 4/20 | 0.66 |
| ▸ | JAK2 | O60674 | 4/20 | 0.66 |
| ▸ | SRC | P12931 | 4/20 | 0.66 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.66 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.63 |
| ▸ | AXL | P30530 | 2/20 | 0.61 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | STK25 | O00506 | 1/20 | 0.59 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | CASK | O14936 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.59 |
| ▸ | MUSK | O15146 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18488277 | 1.00 | JAK3 (0.73) | JAK3ALKINSRIGF1REGFR | |
| SCHEMBL20444222 | 1.00 | JAK3 (0.73) | JAK3ALKINSRIGF1REGFR | |
| SCHEMBL24258103 | 0.93 | JAK3 (0.68) | JAK3ALKINSRIGF1REGFR | |
| SCHEMBL24258104 | 0.93 | JAK3 (0.68) | JAK3ALKINSRIGF1REGFR | |
| SCHEMBL26361378 | 0.92 | JAK3 (0.68) | JAK3ALKINSRIGF1REGFR | |
| SCHEMBL26361376 | 0.92 | JAK3 (0.68) | JAK3ALKINSRIGF1REGFR | |
| SCHEMBL17209893 | 0.85 | JAK3 (1.00) | JAK3ALKEGFRJAK2PLK4 | |
| SCHEMBL24255230 | 0.83 | ALK (0.74) | JAK3ALKINSRIGF1REGFR | |
| SCHEMBL24258110 | 0.82 | ALK (0.67) | JAK3ALKINSRIGF1REGFR | |
| SCHEMBL24258141 | 0.82 | ALK (0.67) | JAK3ALKINSRIGF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023899-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2017-02-09 | — | — | WO | disclosed |