Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2404025 | 0.87 | POLB (0.42) | POLBHTTNPSR1L3MBTL1CYP2C9 | |
| SCHEMBL29889833 | 0.79 | POLB (0.53) | POLBHTTNPSR1L3MBTL1KMT2A | |
| SCHEMBL27436626 | 0.79 | POLB (0.53) | POLBHTTNPSR1L3MBTL1KMT2A | |
| SCHEMBL24977468 | 0.79 | POLB (0.53) | POLBHTTNPSR1L3MBTL1KMT2A | |
| SCHEMBL1999919 | 0.79 | POLB (0.53) | POLBHTTNPSR1L3MBTL1KMT2A | |
| SCHEMBL3385979 | 0.78 | POLB (0.51) | POLBHTTNPSR1L3MBTL1KMT2A | |
| SCHEMBL6387359 | 0.78 | POLB (0.55) | POLBHTTNPSR1L3MBTL1KMT2A | |
| SCHEMBL29794297 | 0.76 | CYP2D6 (0.51) | POLBHTTNPSR1L3MBTL1CYP2C19 | |
| Hydrochloric Acid SCHEMBL21632067 | 0.76 | POLB (0.50) | POLBHTTNPSR1L3MBTL1KMT2A | |
| SCHEMBL467919 | 0.76 | CYP2D6 (0.51) | POLBHTTNPSR1L3MBTL1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027312-A1 | GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2017-02-16 | — | — | WO | disclosed |
| WO-2017027309-A1 | GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2017-02-16 | — | — | WO | disclosed |