Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.69 |
| ▸ | JAK3 | P52333 | 20/20 | 0.69 |
| ▸ | JAK2 | O60674 | 10/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10196372 | 0.88 | JAK1 (0.67) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL10176790 | 0.86 | JAK1 (0.69) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL24021291 | 0.85 | JAK1 (0.66) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL524768 | 0.85 | JAK1 (0.72) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL524815 | 0.84 | JAK1 (0.77) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL15389661 | 0.83 | JAK1 (0.66) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL15389492 | 0.83 | JAK1 (0.70) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL15389446 | 0.83 | JAK1 (0.66) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL10176787 | 0.83 | JAK1 (0.74) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL340351 | 0.83 | JAK1 (0.79) | JAK1JAK3JAK2CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9566283-B2 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2017-02-14 | — | — | US | disclosed |