Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.85 |
| ▸ | FGFR2 | P21802 | 16/20 | 0.85 |
| ▸ | CSF1R | P07333 | 1/20 | 0.68 |
| ▸ | LYN | P07948 | 1/20 | 0.68 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.68 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.68 |
| ▸ | FLT4 | P35916 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 1/20 | 0.68 |
| ▸ | BLK | P51451 | 1/20 | 0.68 |
| ▸ | BMX | P51813 | 1/20 | 0.68 |
| ▸ | JAK3 | P52333 | 1/20 | 0.68 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.68 |
| ▸ | TAOK2 | Q9UL54 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16993128 | 0.92 | FGFR1 (1.00) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL21218251 | 0.91 | FGFR1 (0.86) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL19591943 | 0.89 | FGFR1 (0.84) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL28734446 | 0.85 | FGFR1 (0.84) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL18501667 | 0.84 | FGFR1 (0.86) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL21218188 | 0.84 | FGFR1 (0.86) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL16993396 | 0.83 | FGFR1 (1.00) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL16993205 | 0.83 | FGFR1 (1.00) | FGFR1FGFR2 | |
| SCHEMBL21218217 | 0.83 | FGFR1 (0.86) | FGFR1FGFR2CSF1RLYNFGFR4 | |
| SCHEMBL21218024 | 0.83 | FGFR1 (0.86) | FGFR1FGFR2CSF1RLYNFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567334-B2 | Quinolone derivatives as fibroblast growth factor receptor inhibitors | PRINCIPIA BIOPHARMA, INC. (US) | 2017-02-14 | — | — | US | disclosed |