Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 19/20 | 0.74 |
| ▸ | PIK3CD | O00329 | 18/20 | 0.74 |
| ▸ | PIK3CB | P42338 | 17/20 | 0.74 |
| ▸ | MTOR | P42345 | 9/20 | 0.74 |
| ▸ | PIK3C3 | Q8NEB9 | 5/20 | 0.74 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.70 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.56 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17204058 | 1.00 | PIK3CG (0.74) | PIK3CGPIK3CDPIK3CBMTORPIK3C3 | |
| SCHEMBL18493554 | 1.00 | PIK3CG (0.74) | PIK3CGPIK3CDPIK3CBMTORPIK3C3 | |
| SCHEMBL17203782 | 0.88 | PIK3CG (0.70) | PIK3CGPIK3CDPIK3CBMTORPIK3C3 | |
| SCHEMBL18507177 | 0.87 | PIK3CG (0.69) | PIK3CGPIK3CDPIK3CBMTORPIK3C3 | |
| SCHEMBL18507255 | 0.87 | PIK3CG (0.69) | PIK3CGPIK3CDPIK3CBMTORPIK3C3 | |
| SCHEMBL18507178 | 0.87 | PIK3CG (0.69) | PIK3CGPIK3CDPIK3CBMTORPIK3C3 | |
| SCHEMBL17203807 | 0.87 | PIK3CG (0.73) | PIK3CGPIK3CDPIK3CBMTORPIK3C3 | |
| SCHEMBL17203624 | 0.87 | PIK3CG (0.73) | PIK3CGPIK3CDPIK3CBMTORPIK3C3 | |
| SCHEMBL17206096 | 0.87 | PIK3CG (0.73) | PIK3CGPIK3CDPIK3CBMTORPIK3C3 | |
| SCHEMBL17205743 | 0.87 | PIK3CG (0.73) | PIK3CGPIK3CDPIK3CBMTORPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458979-B | Aminopyrazine derivatives as phosphatidylinositol 3-kinase inhibitors | 诺华股份有限公司 | 2020-03-27 | — | — | CN | claimed |
| CN-106458979-B | Aminopyrazine derivatives as phosphatidylinositol 3-kinase inhibitors | 诺华股份有限公司 | 2020-03-27 | — | — | CN | disclosed |
| US-10004732-B2 | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors | NOVARTIS AG (CH) | 2018-06-26 | — | — | US | disclosed |
| US-20170042889-A1 | AMINO PYRAZINE DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | NOVARTIS AG (CH) | 2017-02-16 | — | — | US | disclosed |
| US-20170042889-A1 | AMINO PYRAZINE DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | NOVARTIS AG (CH) | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10004732-B2 | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors | PI4KA, PIP5K1B, PIP4K2B | PIK3CG 18/4885PIK3CD 15/4885PIK3CB 13/4885 |
| US-20170042889-A1 | AMINO PYRAZINE DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PI4KA, PIP5K1B, PIP4K2B | PIK3CG 18/4885PIK3CD 15/4885PIK3CB 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.