SCHEMBL18503373

SCHEMBL18503373

Cc1ccc(CCc2ccc(-c3ccc(C)cc3)c(F)c2)cc1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.50
CYP1A2 P05177 1/20 0.45
CYP2A6 P11509 1/20 0.45
TAAR1 Q96RJ0 1/20 0.45
RARB P10826 1/20 0.44
PDE3B Q13370 1/20 0.43
PDE3A Q14432 1/20 0.43
FFAR4 Q5NUL3 3/20 0.43
CHKA P35790 1/20 0.42
S1PR1 P21453 1/20 0.42
FFAR1 O14842 2/20 0.41
PTGS2 P35354 2/20 0.41
IGF1R P08069 1/20 0.41
ALOX15 P16050 1/20 0.41
PTGS1 P23219 1/20 0.40
DGAT1 O75907 1/20 0.39
SOAT1 P35610 1/20 0.39
KCNH2 Q12809 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9664122 0.93 RARB (0.47) BACE1CYP1A2CYP2A6TAAR1RARB
SCHEMBL18503378 0.93 BACE1 (0.46) BACE1CYP1A2CYP2A6TAAR1RARB
SCHEMBL9664907 0.91 RARB (0.45) BACE1CYP1A2CYP2A6TAAR1RARB
SCHEMBL14752903 0.91 RARB (0.48) BACE1CYP1A2CYP2A6TAAR1RARB
SCHEMBL19820863 0.91 BACE1 (0.45) BACE1CYP1A2CYP2A6TAAR1RARB
SCHEMBL19820862 0.91 PDE3B (0.46) BACE1CYP1A2CYP2A6TAAR1RARB
SCHEMBL14752904 0.91 BACE1 (0.49) BACE1CYP1A2CYP2A6TAAR1RARB
SCHEMBL19820866 0.91 RARB (0.46) BACE1CYP1A2CYP2A6TAAR1RARB
SCHEMBL9664958 0.91 RARB (0.54) BACE1RARBPDE3BPDE3AS1PR1
SCHEMBL19820864 0.89 PDE3B (0.45) BACE1CYP1A2CYP2A6TAAR1RARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170045765-A1 LCD DEVICE DIC CORPORATION (JP) 2017-02-16 US disclosed