Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 4/20 | 0.49 |
| ▸ | CNR2 | P34972 | 3/20 | 0.49 |
| ▸ | TACR2 | P21452 | 5/20 | 0.38 |
| ▸ | TACR1 | P25103 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2159791 | 0.92 | CNR1 (0.49) | CNR1CNR2TACR2TACR1CYP46A1 | |
| SCHEMBL15063077 | 0.90 | CNR1 (0.47) | CNR1CNR2TACR2TACR1CYP46A1 | |
| SCHEMBL2158511 | 0.89 | CNR1 (0.49) | CNR1CNR2TACR2TACR1 | |
| SCHEMBL2159761 | 0.88 | CNR1 (0.46) | CNR1CNR2TACR2TACR1CYP46A1 | |
| SCHEMBL2158800 | 0.87 | CNR1 (0.45) | CNR1CNR2TACR2TACR1CYP46A1 | |
| SCHEMBL1848051 | 0.86 | CNR1 (0.45) | CNR1CNR2TACR2TACR1CYP46A1 | |
| SCHEMBL1848626 | 0.86 | CNR1 (0.50) | CNR1CNR2TACR2TACR1TP53 | |
| SCHEMBL5099240 | 0.86 | TACR1 (0.46) | CNR1CNR2TACR2TACR1CYP46A1 | |
| SCHEMBL2159789 | 0.86 | CNR1 (0.44) | CNR1CNR2TACR2TACR1CYP46A1 | |
| SCHEMBL1852006 | 0.85 | CNR1 (0.44) | CNR1CNR2TACR2TACR1CYP46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324015-B1 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2013-07-03 | — | — | EP | disclosed |
| EP-2324015-A2 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-aventis (FR) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010012964-A2 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-02-04 | — | — | WO | disclosed |