Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 12/20 | 0.59 |
| ▸ | CSNK2B | P67870 | 12/20 | 0.59 |
| ▸ | CDC7 | O00311 | 11/20 | 0.59 |
| ▸ | CSNK2A1 | P68400 | 10/20 | 0.59 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.42 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851020 | 1.00 | PIM1 (0.59) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL4114444 | 0.90 | PIM1 (0.62) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL4113615 | 0.90 | PIM1 (0.62) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1855901 | 0.89 | PIM1 (0.70) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1849975 | 0.89 | PIM1 (0.70) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1852448 | 0.86 | PIM1 (0.59) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1850649 | 0.86 | PIM1 (0.59) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1850651 | 0.86 | PIM1 (0.59) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1848761 | 0.85 | PIM1 (0.52) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1848762 | 0.85 | PIM1 (0.52) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-B1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS INC (US) | 2011-05-25 | — | — | EP | disclosed |