Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.75 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.75 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.75 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.75 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.75 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.75 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.75 |
| ▸ | EGFR | P00533 | 2/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5477805 | 0.91 | LRRK2 (0.83) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5477806 | 0.91 | LRRK2 (0.83) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5474727 | 0.86 | LRRK2 (0.75) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3804991 | 0.86 | LRRK2 (0.75) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5480443 | 0.86 | LRRK2 (0.75) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14674659 | 0.86 | LRRK2 (0.75) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5474728 | 0.86 | LRRK2 (0.75) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5480439 | 0.86 | LRRK2 (0.75) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14674660 | 0.86 | LRRK2 (0.75) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3755289 | 0.85 | LRRK2 (1.00) | LRRK2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567305-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2017-02-14 | — | — | US | disclosed |