SCHEMBL1850773

SCHEMBL1850773

CCN(CC)CC.CON(C)C(=O)c1cc2cccc(Br)c2s1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK1 P49759 8/20 0.46
DYRK1A Q13627 3/20 0.46
DYRK1B Q9Y463 2/20 0.46
CHRNA1 P02708 1/20 0.38
CHRNB2 P17787 1/20 0.38
CHRNB4 P30926 1/20 0.38
CHRNA4 P43681 1/20 0.38
HDAC3 O15379 2/20 0.36
HDAC4 P56524 2/20 0.36
HDAC1 Q13547 2/20 0.36
HDAC7 Q8WUI4 2/20 0.36
HDAC2 Q92769 2/20 0.36
HDAC10 Q969S8 2/20 0.36
HDAC11 Q96DB2 2/20 0.36
HDAC8 Q9BY41 2/20 0.36
HDAC6 Q9UBN7 2/20 0.36
HDAC9 Q9UKV0 2/20 0.36
HDAC5 Q9UQL6 2/20 0.36
NPC1 O15118 3/20 0.35
RAB9A P51151 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1853849 0.93 CLK1 (0.52) CLK1DYRK1ADYRK1BCHRNA1CHRNB2
SCHEMBL6336721 0.78 CLK1 (0.57) CLK1DYRK1ADYRK1BHDAC3HDAC4
SCHEMBL6329338 0.77 HDAC3 (0.57) CLK1DYRK1ADYRK1BHDAC3HDAC4
SCHEMBL1091054 0.74 HPGD (0.54) CHRNA1CHRNB2CHRNB4CHRNA4HDAC3
SCHEMBL18105639 0.74 CLK1 (0.48) CLK1DYRK1ADYRK1BNPC1RAB9A
SCHEMBL18264002 0.73 KDM4E (0.60) CHRNA1CHRNB2CHRNB4CHRNA4HDAC3
SCHEMBL7205264 0.72 CHRNA1 (0.51) CLK1DYRK1ADYRK1BCHRNA1CHRNB2
SCHEMBL11888470 0.71 CLK1 (0.69) CLK1DYRK1ADYRK1BHDAC3HDAC4
SCHEMBL1091530 0.70 BCL2L1 (0.53) CHRNA1CHRNB2CHRNB4CHRNA4HDAC3
SCHEMBL13295842 0.69 CHRNA1 (0.48) DYRK1ADYRK1BCHRNA1CHRNB2CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2323978-A1 AMIDE COMPOUND Takeda Pharmaceutical Company Limited (JP) 2011-05-25 EP disclosed
WO-2010018874-A1 AMIDE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-02-18 WO disclosed