Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 18/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 5/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15580208 | 0.88 | HDAC6 (1.00) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL18466849 | 0.85 | HDAC1 (0.80) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL18508314 | 0.83 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL19263901 | 0.83 | HDAC1 (0.71) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL18467002 | 0.78 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL18508398 | 0.77 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL19113864 | 0.77 | HDAC6 (1.00) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL13296979 | 0.77 | HDAC3 (0.62) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL13296964 | 0.77 | HDAC3 (0.62) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL18508399 | 0.75 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127903-B1 | 2,2'-TANDEM DITHIAZOLE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2017-08-23 | — | — | EP | disclosed |
| US-9643941-B2 | 2,2′-tandem dithiazole compound, preparation method therefor, and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-05-09 | — | — | US | disclosed |
| US-20170044119-A1 | 2,2'-TANDEM DITHIAZOLE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044119-A1 | 2,2'-TANDEM DITHIAZOLE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | HDAC2, HDAC11, HDAC8 | HDAC1 4/4885HDAC3 27/4885HDAC6 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.