Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.86 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1478915 | 0.93 | CYP1A2 (1.00) | CYP1A2MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL69653 | 0.87 | MAPT (0.64) | CYP1A2MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2832191 | 0.86 | CYP1A2 (0.86) | CYP1A2MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL21639419 | 0.86 | CYP1A2 (0.86) | CYP1A2MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1545927 | 0.85 | CYP1A2 (0.63) | CYP1A2MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29031112 | 0.84 | CYP1A2 (0.83) | CYP1A2MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5452594 | 0.84 | CYP1A2 (0.83) | CYP1A2MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL22701452 | 0.84 | CYP1A2 (0.83) | CYP1A2MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL109583 | 0.84 | CYP1A2 (0.82) | CYP1A2MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9938967 | 0.83 | CYP1A2 (0.80) | CYP1A2MAPTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297103-B1 | HYDROXYPHENYLSULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-01-04 | — | — | EP | disclosed |