Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 14/20 | 0.57 |
| ▸ | IDH2 | P48735 | 10/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15102494 | 0.92 | IDH1 (0.70) | IDH1IDH2ABCB11ADORA3CHRM1 | |
| SCHEMBL29763323 | 0.92 | IDH1 (0.70) | IDH1IDH2ABCB11ADORA3CHRM1 | |
| SCHEMBL29763304 | 0.85 | IDH1 (0.60) | IDH1IDH2 | |
| SCHEMBL15102492 | 0.85 | IDH1 (0.60) | IDH1IDH2 | |
| SCHEMBL15102421 | 0.84 | IDH2 (0.58) | IDH1IDH2ABCB11ADORA3CHRM1 | |
| SCHEMBL15102477 | 0.83 | IDH1 (0.65) | IDH1IDH2ABCB11ADORA3CHRM1 | |
| SCHEMBL15102452 | 0.83 | IDH1 (0.71) | IDH1IDH2 | |
| SCHEMBL29763268 | 0.83 | IDH1 (0.71) | IDH1IDH2 | |
| SCHEMBL29560264 | 0.81 | IDH1 (0.71) | IDH1IDH2 | |
| SCHEMBL15102434 | 0.81 | IDH1 (0.71) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9656999-B2 | Therapeutically active compounds and their methods of use | AGIOS PHARMACEUTICALS, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| US-20170044139-A1 | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE | SERVIER PHARMACEUTICALS LLC | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044139-A1 | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE | MCL1, TP53, BRDT | IDH1 172/4885IDH2 110/4885ABCB11 3051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.