Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | IL1RN | P18510 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184891 | 0.98 | GCK (0.49) | GCKPPARGPPARAMAPTIL1RN | |
| SCHEMBL19921743 | 0.97 | GCK (0.51) | GCKPPARGPPARAMAPTIL1RN | |
| SCHEMBL185307 | 0.88 | GCK (0.58) | GCKPPARGPPARAMAPTKMT2A | |
| SCHEMBL185276 | 0.87 | GCK (0.47) | GCKMAPTMEN1KMT2AGFER | |
| SCHEMBL184988 | 0.86 | GCK (0.60) | GCKPPARGPPARAMAPTKMT2A | |
| SCHEMBL184698 | 0.85 | GCK (0.61) | GCKPPARGPPARAMEN1KMT2A | |
| SCHEMBL184331 | 0.80 | GCK (0.60) | GCKLMNA | |
| SCHEMBL185194 | 0.80 | GCK (0.63) | GCKLMNA | |
| SCHEMBL184524 | 0.79 | GCK (0.61) | GCKPPARGPPARAKMT2APKM | |
| SCHEMBL185473 | 0.79 | GCK (0.57) | GCKMAPTMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402327-B1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | IMPETIS BIOSCIENCES LTD (IN) | 2018-03-07 | — | — | EP | disclosed |
| EP-2402327-A1 | Acetamide compounds as glucokinase activators, their process and medicinal applications | Advinus Therapeutics Private Limited (IN) | 2012-01-04 | — | — | EP | disclosed |