Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.53 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18524634 | 0.91 | SYK (0.47) | SYKCYP2D6KCNH2MAPK1 | |
| SCHEMBL14737663 | 0.85 | SYK (0.71) | SYKCYP2D6KCNH2JAK2JAK1 | |
| SCHEMBL18524700 | 0.85 | SYK (0.53) | SYKMAP2K4MAPK1GSK3BJAK2 | |
| SCHEMBL18524593 | 0.84 | SYK (0.52) | SYKMAP2K4MAPK1JAK2JAK1 | |
| SCHEMBL18524474 | 0.84 | SYK (0.75) | SYKCYP2D6KCNH2JAK2JAK1 | |
| SCHEMBL18524878 | 0.83 | SYK (0.44) | SYKCYP2D6 | |
| SCHEMBL18524671 | 0.82 | SYK (0.45) | SYKCYP2D6KCNH2 | |
| SCHEMBL18524743 | 0.81 | SYK (0.43) | SYKCYP2D6KCNH2MAPK1 | |
| SCHEMBL18524633 | 0.81 | SYK (0.52) | SYKMAP2K4CYP2D6MAPK1 | |
| SCHEMBL14752605 | 0.78 | SYK (0.69) | SYKCYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | claimed |