Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 14/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | LTK | P29376 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | PRKX | P51817 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18524821 | 0.87 | SYK (0.42) | SYKCYP2D6MAPK1AURKACSF1R | |
| SCHEMBL14738655 | 0.83 | SYK (0.59) | TYRO3SYKCYP2D6KCNH2 | |
| SCHEMBL18524882 | 0.83 | MAPK1 (0.41) | SYKCYP2D6MAPK1 | |
| Hydrochloric Acid SCHEMBL14737871 | 0.82 | SYK (0.58) | TYRO3SYKCYP2D6KCNH2 | |
| SCHEMBL18524557 | 0.79 | SYK (0.43) | SYKCYP2D6KDRKCNH2 | |
| SCHEMBL18524738 | 0.78 | SYK (0.46) | SYKCYP2D6KCNH2 | |
| SCHEMBL18535128 | 0.77 | SYK (0.45) | TYRO3SYKCYP2D6MAPK1PLK4 | |
| SCHEMBL18524547 | 0.76 | SYK (0.49) | SYKCYP2D6KCNH2 | |
| SCHEMBL18524782 | 0.76 | SYK (0.54) | SYKCYP2D6KCNH2 | |
| SCHEMBL18524617 | 0.76 | SYK (0.53) | SYKCYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | claimed |