Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18524598 | 0.92 | SYK (0.58) | SYKKCNH2CYP2C9CYP2D6JAK2 | |
| SCHEMBL18524847 | 0.91 | SYK (0.58) | SYKKCNH2CYP2C9CYP2D6JAK2 | |
| SCHEMBL18524790 | 0.89 | SYK (0.60) | SYKCYP2C9CYP2D6JAK2JAK1 | |
| SCHEMBL18524887 | 0.88 | SYK (0.74) | SYKCYP2C9CYP2D6JAK2JAK1 | |
| SCHEMBL14738718 | 0.87 | SYK (0.77) | SYKKCNH2CYP2C9CYP2D6JAK2 | |
| SCHEMBL18524816 | 0.87 | SYK (0.57) | SYKKCNH2CYP2C9CYP2D6JAK2 | |
| SCHEMBL18524555 | 0.87 | SYK (0.74) | SYKCYP2C9CYP2D6JAK2JAK1 | |
| SCHEMBL18524456 | 0.85 | SYK (0.77) | SYKKCNH2CYP2C9CYP2D6JAK2 | |
| SCHEMBL18524881 | 0.85 | SYK (0.56) | SYKKCNH2CYP2C9CYP2D6JAK2 | |
| SCHEMBL18524795 | 0.85 | SYK (0.57) | SYKCYP2D6JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | claimed |