SCHEMBL185254

SCHEMBL185254

CCOC(=O)c1ccc(Oc2cnc(NC(=O)C(Oc3cccc(C(F)(F)F)c3)c3ccc(S(=O)(=O)C4CC4)cc3)s2)cc1

nearest known ligand 0.67

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
GCK P35557 20/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3766408 0.94 GCK (0.61) GCK
SCHEMBL184622 0.91 GCK (0.69) GCK
SCHEMBL185212 0.91 GCK (0.70) GCK
SCHEMBL184482 0.86 GCK (0.62) GCK
SCHEMBL185211 0.84 GCK (0.69) GCK
SCHEMBL184752 0.83 GCK (0.72) GCK
SCHEMBL185070 0.83 GCK (0.65) GCK
SCHEMBL185758 0.82 GCK (0.62) GCK
SCHEMBL185973 0.81 GCK (0.63) GCK
SCHEMBL184688 0.81 GCK (0.69) GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2402327-A1 Acetamide compounds as glucokinase activators, their process and medicinal applications Advinus Therapeutics Private Limited (IN) 2012-01-04 EP claimed