Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856691 | 1.00 | CNR2 (0.72) | CNR2POLBMEN1KMT2AEPHX2 | |
| SCHEMBL8695595 | 0.91 | CNR2 (0.72) | CNR2POLBMEN1KMT2AEPHX2 | |
| SCHEMBL31616456 | 0.90 | CNR2 (0.70) | CNR2POLBMEN1KMT2AEPHX2 | |
| SCHEMBL15087599 | 0.85 | CNR2 (0.97) | CNR2POLBMEN1KMT2AEPHX2 | |
| SCHEMBL18896343 | 0.85 | POLB (0.69) | CNR2POLBMEN1KMT2ACNR1 | |
| SCHEMBL15064314 | 0.84 | CNR2 (1.00) | CNR2POLBMEN1KMT2ACNR1 | |
| SCHEMBL31661673 | 0.83 | CNR2 (0.72) | CNR2POLBMEN1KMT2A | |
| SCHEMBL27659273 | 0.82 | POLB (0.66) | CNR2POLBMEN1KMT2ACNR1 | |
| SCHEMBL27659274 | 0.82 | POLB (0.66) | CNR2POLBMEN1KMT2ACNR1 | |
| SCHEMBL18884739 | 0.82 | POLB (0.54) | CNR2POLBMEN1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | disclosed |
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |