Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13494218 | 1.00 | CCR1 (0.40) | CCR1CYP2C19PSEN1PSEN2APH1B | |
| SCHEMBL754124 | 1.00 | CCR1 (0.40) | CCR1CYP2C19PSEN1PSEN2APH1B | |
| SCHEMBL753954 | 1.00 | CCR1 (0.40) | CCR1CYP2C19PSEN1PSEN2APH1B | |
| SCHEMBL753201 | 0.96 | PSEN1 (0.42) | CCR1CYP2C19PSEN1PSEN2APH1B | |
| SCHEMBL16790009 | 0.96 | PSEN1 (0.42) | CCR1CYP2C19PSEN1PSEN2APH1B | |
| SCHEMBL756381 | 0.96 | PSEN1 (0.42) | CCR1CYP2C19PSEN1PSEN2APH1B | |
| SCHEMBL10076895 | 0.86 | MAPT (0.47) | CCR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8919233 | 0.86 | MAPT (0.47) | CCR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10151230 | 0.86 | MAPT (0.47) | CCR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13888655 | 0.85 | NPSR1 (0.41) | CCR1KDM4ETSHRHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601188-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-10-18 | — | — | EP | disclosed |
| EP-2513091-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-04-12 | — | — | EP | disclosed |
| EP-2499132-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-02-15 | — | — | EP | disclosed |