Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | TNKS | O95271 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2J2 | P51589 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.35 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18530356 | 1.00 | EPHX2 (0.47) | EPHX2GRIN1GRIN2BTNKSPARP1 | |
| SCHEMBL4963265 | 0.86 | EPHX2 (0.51) | EPHX2TNKSPARP1PARP2TNKS2 | |
| SCHEMBL4963257 | 0.86 | EPHX2 (0.51) | EPHX2TNKSPARP1PARP2TNKS2 | |
| Hydrochloric Acid SCHEMBL20357430 | 0.84 | EPHX2 (0.50) | EPHX2TNKSPARP1PARP2TNKS2 | |
| SCHEMBL23924232 | 0.82 | EPHX2 (0.48) | EPHX2ALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL23924231 | 0.82 | EPHX2 (0.48) | EPHX2ALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL23924051 | 0.82 | EPHX2 (0.51) | EPHX2GRIN1GRIN2BTNKSPARP1 | |
| SCHEMBL23924049 | 0.82 | EPHX2 (0.51) | EPHX2GRIN1GRIN2BTNKSPARP1 | |
| SCHEMBL23924020 | 0.81 | EPHX2 (0.54) | EPHX2GRIN1GRIN2BLMNAFAAH | |
| SCHEMBL23924019 | 0.81 | EPHX2 (0.54) | EPHX2GRIN1GRIN2BLMNAFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3337476-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS | Arvinas, Inc. (US) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017030814-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS | Arvinas, Inc. (US) | 2017-02-23 | — | — | WO | disclosed |