Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.74 |
| ▸ | EGFR | P00533 | 6/20 | 0.73 |
| ▸ | LCK | P06239 | 6/20 | 0.73 |
| ▸ | ITK | Q08881 | 5/20 | 0.73 |
| ▸ | JAK3 | P52333 | 4/20 | 0.73 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.58 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15517391 | 0.88 | BTK (0.72) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL15517319 | 0.86 | BTK (0.81) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL18533099 | 0.86 | BTK (0.75) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL17090646 | 0.86 | BTK (0.80) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL13860105 | 0.85 | BTK (1.00) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL13860104 | 0.85 | BTK (1.00) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL14617791 | 0.85 | BTK (0.78) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL409209 | 0.84 | BTK (0.75) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL408564 | 0.84 | BTK (1.00) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL18533075 | 0.83 | BTK (0.74) | BTKEGFRLCKITKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9572811-B2 | Treatment of dry eye | PRINCIPIA BIOPHARMA INC. (US) | 2017-02-21 | — | — | US | disclosed |