Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 5/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | GAA | P10253 | 1/20 | 0.80 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.80 |
| ▸ | HPGD | P15428 | 1/20 | 0.80 |
| ▸ | TSHR | P16473 | 1/20 | 0.80 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.80 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | DHFR | P00374 | 7/20 | 0.54 |
| ▸ | ATIC | P31939 | 3/20 | 0.54 |
| ▸ | GART | P22102 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19738969 | 1.00 | TYMS (0.80) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL23193099 | 0.95 | TYMS (0.81) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL18897683 | 0.92 | TYMS (0.85) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL844389 | 0.92 | TYMS (0.85) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL22618801 | 0.92 | TYMS (0.85) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL13575164 | 0.92 | TYMS (0.84) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL13011046 | 0.92 | TYMS (0.84) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL22055304 | 0.91 | TYMS (0.82) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL23921299 | 0.91 | TYMS (0.82) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL19741556 | 0.91 | TYMS (0.82) | TYMSKDM4EMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231194-B1 | FOLATE-IRNA CONJUGATES | ALNYLAM PHARMACEUTICALS INC (US) | 2017-02-22 | — | — | EP | disclosed |