Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.81 |
| ▸ | HPGD | P15428 | 6/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.81 |
| ▸ | POLB | P06746 | 3/20 | 0.81 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.81 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.81 |
| ▸ | CLK2 | P49760 | 1/20 | 0.81 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634923 | 0.91 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL1859195 | 0.91 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL9202394 | 0.91 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL5179063 | 0.90 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| Gatifloxacin SCHEMBL22591 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| Gatifloxacin SCHEMBL2224369 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| (R)-Gatifloxacin SCHEMBL5670068 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| (S)-Gatifloxacin SCHEMBL30910969 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| Gatifloxacin SCHEMBL29356306 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| (S)-Gatifloxacin SCHEMBL22592 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408034-B2 | Use of Quinolone and Quinolizinone derivatives as chemotherapeutic agents | BAYER INNOVATION GMBH (DE) | 2011-05-25 | — | — | EP | claimed |
| EP-1253149-B1 | SULFATE SALT OF QUINOLONECARBOXYLIC ACID DERIVATIVE AND USE THEREOF | KYORIN SEIYAKU KK (JP) | 2007-09-12 | — | — | EP | claimed |
| EP-1408034-B1 | Use of Quinolone and Quinolizinone derivatives as chemotherapeutic agents | SCHULZ & SCHLIMBACH GBR (DE) | 2007-08-08 | — | — | EP | claimed |
| EP-1492535-B1 | ANHYDROUS CRYSTALLINE FORMS I AND II OF 1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-(3-METHYL-1-PIPERAZINYL) 4-OXO-1, 4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID (GATIFLOXACIN) | REDDYS LAB LTD DR (IN) | 2005-10-26 | — | — | EP | claimed |
| EP-1408034-A1 | Use of Quinoline derivatives as antibacterial agents | Schulz & Schlimbach GbR (DE) | 2004-04-14 | — | — | EP | claimed |
| EP-1244434-B1 | USE OF CHEMOTHERAPEUTIC AGENTS | SCHULZ & SCHLIMBACH GBR (DE) | 2004-03-17 | — | — | EP | claimed |
| EP-1244434-A2 | USE OF CHEMOTHERAPEUTIC AGENTS | Schulz, Hans-Herrmann (DE) | 2002-10-02 | — | — | EP | claimed |
| WO-2001045679-A2 | USE OF CHEMOTHERAPEUTIC AGENTS FOR TOPICAL TREATMENT | SCHULZ HANS HERRMANN (DE) | 2001-06-28 | — | — | WO | claimed |
| EP-1408034-B2 | Use of Quinolone and Quinolizinone derivatives as chemotherapeutic agents | BAYER INNOVATION GMBH (DE) | 2011-05-25 | — | — | EP | disclosed |
| EP-1408034-B1 | Use of Quinolone and Quinolizinone derivatives as chemotherapeutic agents | SCHULZ & SCHLIMBACH GBR (DE) | 2007-08-08 | — | — | EP | disclosed |
| EP-1034173-B1 | METHOD FOR PRODUCING 8-METHOXY-QUINOLINE CARBOXYLIC ACIDS | BAYER HEALTHCARE AG (DE) | 2005-04-27 | — | — | EP | disclosed |
| EP-1408034-A1 | Use of Quinoline derivatives as antibacterial agents | Schulz & Schlimbach GbR (DE) | 2004-04-14 | — | — | EP | disclosed |
| EP-1077703-B1 | ORAL MEDICINAL PREPARATIONS WITH REPRODUCIBLE RELEASE OF THE ACTIVE INGREDIENT GATIFLOXACIN OR ITS PHARMACEUTICALLY SUITABLE SALTS OR HYDRATES | GRUENENTHAL GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |