Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.46 |
| ▸ | SYK | P43405 | 4/20 | 0.44 |
| ▸ | JAK2 | O60674 | 13/20 | 0.42 |
| ▸ | JAK1 | P23458 | 13/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18534798 | 0.92 | JAK3 (0.40) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18534555 | 0.92 | JAK3 (0.40) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18534556 | 0.92 | JAK3 (0.40) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18534605 | 0.91 | JAK3 (0.51) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18535067 | 0.90 | SYK (0.39) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18534585 | 0.90 | SYK (0.39) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18535070 | 0.90 | SYK (0.39) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18534854 | 0.90 | SYK (0.40) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18534821 | 0.90 | JAK3 (0.47) | JAK3SYKJAK2JAK1CYP2C9 | |
| SCHEMBL18535040 | 0.90 | SYK (0.40) | JAK3SYKJAK2JAK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |