Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18534731 | 0.92 | SYK (0.59) | SYKKCNH2CYP2D6CYP2C9 | |
| SCHEMBL18535194 | 0.91 | SYK (0.51) | SYKKCNH2CYP2D6 | |
| SCHEMBL18535133 | 0.87 | SYK (0.58) | SYKKCNH2CYP2D6CYP2C9 | |
| SCHEMBL18535189 | 0.87 | JAK3 (0.48) | SYKCYP2C9 | |
| SCHEMBL14751423 | 0.85 | MAPT (0.47) | SYKKCNH2CYP2D6CYP2C9 | |
| SCHEMBL18534887 | 0.84 | SYK (0.50) | SYKKCNH2CYP2D6 | |
| SCHEMBL18534777 | 0.83 | SYK (0.52) | SYKKCNH2CYP2D6CYP2C9 | |
| SCHEMBL18535051 | 0.83 | SYK (0.52) | SYKKCNH2CYP2D6CYP2C9 | |
| SCHEMBL18534801 | 0.83 | SYK (0.49) | SYKCYP2D6 | |
| SCHEMBL18534859 | 0.83 | SYK (0.51) | SYKKCNH2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |