Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.51 |
| ▸ | JAK1 | P23458 | 11/20 | 0.51 |
| ▸ | JAK3 | P52333 | 10/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 9/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14746432 | 1.00 | JAK2 (0.51) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14751202 | 1.00 | JAK2 (0.51) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14746566 | 1.00 | JAK2 (0.51) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14752223 | 0.92 | SYK (0.49) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14752133 | 0.92 | SYK (0.49) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14751066 | 0.92 | SYK (0.49) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14751262 | 0.92 | SYK (0.47) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14751105 | 0.92 | SYK (0.47) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14747010 | 0.91 | SYK (0.46) | JAK2JAK1JAK3TYK2SYK | |
| SCHEMBL14737515 | 0.89 | SYK (0.43) | JAK2JAK1JAK3TYK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |