Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | LPO | P22079 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19117686 | 0.78 | CYP2A6 (0.41) | PIK3CBMAPTSCN9A | |
| SCHEMBL29942174 | 0.76 | RXFP1 (0.35) | PIK3CBMAPTSCN9ALPO | |
| SCHEMBL22863238 | 0.76 | PIK3CB (0.34) | PIK3CBMAPTSCN9ALPO | |
| SCHEMBL20987529 | 0.76 | PIK3CB (0.38) | PIK3CBMAPTSCN9ALPO | |
| SCHEMBL3570930 | 0.76 | RXFP1 (0.35) | PIK3CBMAPTSCN9ALPO | |
| SCHEMBL23346951 | 0.76 | PIK3CB (0.42) | PIK3CBMAPT | |
| SCHEMBL29777078 | 0.76 | PIK3CB (0.34) | PIK3CBMAPTSCN9ALPO | |
| SCHEMBL22863378 | 0.73 | MAPT (0.40) | PIK3CBMAPTSCN9ACDK4CCND1 | |
| SCHEMBL30122603 | 0.73 | RXFP1 (0.33) | PIK3CBMAPTSCN9A | |
| SCHEMBL19759422 | 0.73 | HASPIN (0.33) | PIK3CBMAPTSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |