Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.57 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | KRAS | P01116 | 1/20 | 0.50 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16148690 | 0.90 | POLB (0.81) | POLBKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL20106695 | 0.88 | POLB (0.78) | POLBKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL11819475 | 0.81 | GRIN1 (0.74) | POLBKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL29822900 | 0.81 | SMN1; SMN2 (0.67) | POLBALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL27681975 | 0.81 | SMN1; SMN2 (0.67) | POLBALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7986158 | 0.80 | POLB (0.66) | POLBKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL16147888 | 0.79 | POLB (0.65) | POLBKDM4EHPGDSMN1; SMN2NPC1 | |
| SCHEMBL16147978 | 0.79 | POLB (0.64) | POLBKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL15643368 | 0.78 | POLB (0.64) | POLBKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30902073 | 0.78 | SMN1; SMN2 (0.69) | POLBSMN1; SMN2NPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083819-B1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORP (US) | 2017-02-22 | — | — | EP | disclosed |