Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | SNCA | P37840 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL429342 | 0.90 | MAPT (0.70) | MAPTALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL19000074 | 0.79 | MAPT (0.62) | MAPTALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL22645034 | 0.78 | NPC1 (0.58) | KMT2AMEN1NPC1RAB9ACYP2C19 | |
| SCHEMBL22644972 | 0.78 | NPC1 (0.55) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL22645032 | 0.77 | NPC1 (0.54) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL22645033 | 0.76 | NPC1 (0.59) | KMT2ASNCAMEN1NPC1RAB9A | |
| SCHEMBL22645038 | 0.76 | NPC1 (0.53) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL22644969 | 0.76 | TRPV1 (0.53) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL424896 | 0.75 | MAPT (0.83) | MAPTALDH1A1KMT2AKDM4ENPSR1 | |
| SCHEMBL22644968 | 0.75 | NPC1 (0.58) | MAPTALDH1A1KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2400845-B1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECH INC (US) | 2017-02-22 | — | — | EP | disclosed |