Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 17/20 | 1.00 |
| ▸ | CSNK2B | P67870 | 17/20 | 1.00 |
| ▸ | PIM1 | P11309 | 16/20 | 1.00 |
| ▸ | PIM3 | Q86V86 | 16/20 | 1.00 |
| ▸ | PIM2 | Q9P1W9 | 16/20 | 1.00 |
| ▸ | PTGES | O14684 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1854002 | 0.92 | CSNK2B (0.86) | CSNK2A2CSNK2BPIM1PIM3PIM2 | |
| SCHEMBL1848324 | 0.92 | CSNK2B (0.86) | CSNK2A2CSNK2BPIM1PIM3PIM2 | |
| SCHEMBL1852382 | 0.84 | PIM1 (1.00) | CSNK2A2CSNK2BPIM1PIM3PIM2 | |
| SCHEMBL1850665 | 0.83 | CSNK2A2 (1.00) | CSNK2A2CSNK2BPIM1PIM3PIM2 | |
| SCHEMBL1850401 | 0.83 | CSNK2A2 (1.00) | CSNK2A2CSNK2BPIM1PIM3PIM2 | |
| SCHEMBL1850682 | 0.83 | CSNK2B (0.70) | CSNK2A2CSNK2BPIM1PIM3PIM2 | |
| SCHEMBL1855477 | 0.83 | CSNK2B (0.76) | CSNK2A2CSNK2BPIM1PIM3PIM2 | |
| SCHEMBL1855496 | 0.80 | PIM1 (0.89) | CSNK2A2CSNK2BPIM1PIM3PIM2 | |
| SCHEMBL1849631 | 0.80 | PIM1 (1.00) | CSNK2A2CSNK2BPIM1PIM3PIM2 | |
| SCHEMBL1849424 | 0.80 | CSNK2A2 (1.00) | CSNK2A2CSNK2BPIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247559-A1 | Benzofuropyrimidinones | EXELIXIS, INC. (US) | 2009-10-01 | — | — | US | claimed |
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | claimed |
| EP-2097419-B1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS INC (US) | 2011-05-25 | — | — | EP | disclosed |
| US-20090247559-A1 | Benzofuropyrimidinones | EXELIXIS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247559-A1 | Benzofuropyrimidinones | EXELIXIS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
| US-20090247559-A1 | Benzofuropyrimidinones | EXELIXIS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247559-A1 | Benzofuropyrimidinones | F12, BRI3BP, BRD1 | CSNK2A2 906/4885CSNK2B 350/4885PIM1 1977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.