Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD5 | P21918 | 1/20 | 0.65 |
| ▸ | SCNN1A | P37088 | 1/20 | 0.65 |
| ▸ | SCNN1B | P51168 | 1/20 | 0.65 |
| ▸ | SCNN1G | P51170 | 1/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.65 |
| ▸ | SMO | Q99835 | 4/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.32 |
| ▸ | ATR | Q13535 | 3/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | PAK4 | O96013 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18538916 | 0.94 | DRD5 (0.62) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18538928 | 0.94 | DRD5 (0.66) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL20032720 | 0.90 | DRD5 (0.69) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18538930 | 0.87 | DRD5 (0.64) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL20032718 | 0.86 | DRD5 (0.67) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18538900 | 0.86 | DRD5 (0.66) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18541250 | 0.85 | DRD5 (0.55) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL20348264 | 0.83 | DRD5 (0.63) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18538911 | 0.83 | HRH3 (0.70) | DRD5SCNN1ASCNN1BSCNN1GHRH3 | |
| SCHEMBL18538922 | 0.82 | DRD5 (0.69) | DRD5SCNN1ASCNN1BSCNN1GHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186774-A1 | NOVEL ANNELATED BENZAMIDES | BOEHRINGER INGELHEIM INT (DE) | 2018-07-05 | — | — | US | disclosed |
| US-9938256-B2 | Annelated benzamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-04-10 | — | — | US | disclosed |
| US-20170050952-A1 | NOVEL ANNELATED BENZAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050952-A1 | NOVEL ANNELATED BENZAMIDES | HDAC10, HDAC11, H1-0 | DRD5 608/4885SCNN1A 667/4885SCNN1B 1056/4885 |
| US-20180186774-A1 | NOVEL ANNELATED BENZAMIDES | HDAC10, HDAC11, H1-0 | DRD5 608/4885SCNN1A 667/4885SCNN1B 1056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.