Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18540637 | 0.92 | MAPT (0.44) | MAPTNOS1LMNACYP3A4ALOX15 | |
| SCHEMBL18540585 | 0.86 | MAPT (0.37) | MAPTLMNAPLA2G1BATG4BALDH1A1 | |
| SCHEMBL17212988 | 0.84 | MAPT (0.44) | MAPTNOS1LMNACYP3A4ALOX15 | |
| SCHEMBL18540491 | 0.84 | MAPT (0.39) | MAPTLMNAPLA2G1BATG4BALDH1A1 | |
| SCHEMBL18540476 | 0.82 | ATM (0.36) | MAPTLMNAPLA2G1BATG4BPOLB | |
| SCHEMBL21764015 | 0.81 | FGFR1 (0.38) | FGFR1FGFR2FGFR3ARGRK6 | |
| SCHEMBL18540474 | 0.80 | MAPT (0.38) | MAPTLMNAPLA2G1BATG4BALDH1A1 | |
| SCHEMBL18540482 | 0.80 | MEN1 (0.40) | MAPTLMNAALOX15PLA2G1BATG4B | |
| SCHEMBL18540484 | 0.80 | AR (0.35) | MAPTPLA2G1BATG4BALDH1A1MITF | |
| SCHEMBL18552403 | 0.80 | FGFR1 (0.42) | MAPTLMNAFGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170050939-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050939-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | GRK6, GRK2, GRK3 | MAPT 4031/4885NOS1 3165/4885LMNA 4606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.