Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 5/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | TPMT | P51580 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18540527 | 0.93 | GRK6 (0.49) | GRK6TP53MAPTPOLBALDH1A1 | |
| SCHEMBL14907854 | 0.91 | GRK6 (0.64) | GRK6BRD4TPMTTP53ALDH1A1 | |
| SCHEMBL18540537 | 0.88 | GRK6 (0.49) | GRK6LMNA | |
| SCHEMBL18540542 | 0.85 | GRK6 (0.52) | GRK6MAPTALDH1A1MAPK1PARP1 | |
| SCHEMBL14907788 | 0.83 | GRK6 (0.61) | GRK6TP53MAPTPOLBALDH1A1 | |
| SCHEMBL18540511 | 0.83 | GRK6 (0.53) | GRK6ALDH1A1 | |
| SCHEMBL18540521 | 0.80 | GRK6 (0.47) | GRK6TP53MAPTPOLBALDH1A1 | |
| SCHEMBL18540541 | 0.79 | GRK6 (0.56) | GRK6MAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL28508948 | 0.79 | KDM4E (0.53) | GRK6TP53MAPTPOLBALDH1A1 | |
| SCHEMBL18540515 | 0.79 | GRK6 (0.53) | GRK6TP53MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170050939-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050939-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | GRK6, GRK2, GRK3 | GRK6 1/4885BRD4 842/4885TPMT 2332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.