Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.58 |
| ▸ | EGFR | P00533 | 5/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.58 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.56 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.56 |
| ▸ | TUBB | P07437 | 4/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.56 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.56 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.56 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.56 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.56 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.56 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.56 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.56 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.56 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17528560 | 0.88 | KDR (0.58) | KDREGFRPDGFRBTUBB3ABCB1 | |
| SCHEMBL18540823 | 0.85 | KDR (0.56) | KDREGFRPDGFRBTUBB3ABCB1 | |
| SCHEMBL23732339 | 0.83 | KDR (0.53) | KDREGFRPDGFRBTUBB3ABCB1 | |
| SCHEMBL18552703 | 0.82 | KDR (0.52) | KDREGFRPDGFRBTUBB3ABCB1 | |
| SCHEMBL17528563 | 0.82 | KDR (0.58) | KDREGFRPDGFRBTUBB3ABCB1 | |
| SCHEMBL17528559 | 0.79 | KDR (0.56) | KDREGFRPDGFRBTUBB3ABCB1 | |
| SCHEMBL17528562 | 0.79 | KDR (0.59) | KDREGFRPDGFRBTUBB3ABCB1 | |
| SCHEMBL3110659 | 0.78 | KDR (0.68) | KDREGFRPDGFRBTUBB3ABCB1 | |
| SCHEMBL2256222 | 0.78 | KDR (0.68) | KDREGFRPDGFRBTUBB3ABCB1 | |
| SCHEMBL17528561 | 0.78 | KDR (0.53) | KDREGFRPDGFRBTUBB3ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-08-03 | — | — | US | disclosed |
| US-10457688-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2019-10-29 | — | — | US | disclosed |
| US-9994586-B2 | Monocyclic, thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-12 | — | — | US | disclosed |
| US-9994586-B2 | Monocyclic, thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-12 | — | — | US | disclosed |
| WO-2017031176-A1 | MONOCYCLIC, THIENO, PYRIDO, AND PYRROLO PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE OF THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2017-02-23 | — | — | WO | disclosed |
| US-20170050978-A1 | Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2017-02-23 | — | — | US | disclosed |
| US-20170050978-A1 | Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DPYD, TYMS, THPO | KDR 2597/4885EGFR 2600/4885PDGFRB 1782/4885 |
| US-10457688-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DPYD, TPX2, TYMS | KDR 3311/4885EGFR 3522/4885PDGFRB 2239/4885 |
| US-20170050978-A1 | Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same | CYP4F3, TYMS, DPYD | KDR 1696/4885EGFR 1667/4885PDGFRB 1108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.