Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 20/20 | 0.58 |
| ▸ | CSNK2B | P67870 | 20/20 | 0.58 |
| ▸ | CDC7 | O00311 | 16/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 16/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 9/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 9/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851552 | 0.85 | PIM1 (0.71) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL4127668 | 0.84 | PIM1 (0.49) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL4107226 | 0.83 | PIM1 (0.68) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| Acetic Acid SCHEMBL1868244 | 0.81 | PIM1 (0.64) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1855473 | 0.81 | PIM1 (0.61) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL4280976 | 0.81 | PIM1 (0.71) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1854292 | 0.80 | PIM1 (0.70) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1852943 | 0.80 | PIM1 (0.69) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1850343 | 0.80 | PIM1 (0.75) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL4107579 | 0.79 | PIM1 (0.74) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-B1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS INC (US) | 2011-05-25 | — | — | EP | disclosed |