Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.58 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1853311 | 0.98 | PTPN1 (0.56) | PTPN1EYA3TTRKDM4AKDM5A | |
| SCHEMBL2985777 | 0.95 | PTPN1 (0.53) | PTPN1EYA3TTRKDM4AKDM5A | |
| SCHEMBL8810393 | 0.84 | PTPN1 (0.61) | PTPN1EYA3TTRTHRATHRB | |
| SCHEMBL11218137 | 0.83 | PTPN1 (0.57) | PTPN1EYA3TTR | |
| Hydrochloric Acid SCHEMBL8732680 | 0.83 | PTPN1 (0.60) | PTPN1EYA3TTRTHRATHRB | |
| SCHEMBL13049676 | 0.78 | PTPN1 (0.55) | PTPN1EYA3TTRTHRATHRB | |
| SCHEMBL21555485 | 0.78 | PTPN1 (0.52) | PTPN1EYA3TTR | |
| SCHEMBL6718612 | 0.78 | PTPN1 (0.56) | PTPN1EYA3TTRTHRATHRB | |
| SCHEMBL11402772 | 0.78 | PTPN1 (0.50) | PTPN1EYA3 | |
| SCHEMBL24026894 | 0.77 | PTPN1 (0.51) | PTPN1EYA3TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | disclosed |