SCHEMBL18551128

C[C@H](NC(=O)OC(C)(C)C)c1ccc(N2CCN(C(=O)CCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(N)=O)C(C)(C)C)CC2)cc1

nearest known ligand 0.43

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	LRRK2	Q5S007	2/20	0.43

▸	VHL	P40337	4/20	0.41

▸	ELOC	Q15369	2/20	0.41

▸	ELOB	Q15370	2/20	0.41

▸	SOS1	Q07889	3/20	0.40

▸	PRMT5	O14744	2/20	0.39

▸	WDR77	Q9BQA1	2/20	0.39

▸	CDK4	P11802	1/20	0.38

▸	CCND1	P24385	1/20	0.38

▸	CCND3	P30281	1/20	0.38

▸	CDK6	Q00534	1/20	0.38

▸	EGFR	P00533	5/20	0.37

▸	NAMPT	P43490	4/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL18551121	0.85	LRRK2 (0.60)	LRRK2VHLELOCELOBSOS1
SCHEMBL25413778	0.80	VHL (0.62)	LRRK2VHLELOCELOBSOS1
SCHEMBL18530412	0.80	VHL (0.62)	LRRK2VHLELOCELOBSOS1
SCHEMBL18530416	0.80	VHL (0.62)	LRRK2VHLELOCELOBSOS1
SCHEMBL18530448	0.79	MAPT (0.41)	—
SCHEMBL18530398	0.79	MAPT (0.41)	—
SCHEMBL18530426	0.79	VHL (0.60)	LRRK2VHLELOCELOBSOS1
SCHEMBL25414216	0.79	VHL (0.60)	LRRK2VHLELOCELOBSOS1
SCHEMBL18530428	0.79	VHL (0.60)	LRRK2VHLELOCELOBSOS1
SCHEMBL18591877	0.79	VHL (0.62)	LRRK2VHLELOCELOBSOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017030814-A1	COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS	Arvinas, Inc. (US)	2017-02-23	—	—	WO	disclosed