Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295063 | 0.88 | SYK (0.55) | SYKKDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL1855309 | 0.83 | SYK (0.51) | SYKKDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL2297975 | 0.81 | SYK (0.60) | SYKPRKDC | |
| SCHEMBL1858428 | 0.80 | SYK (0.56) | SYKKDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL2588826 | 0.80 | PIK3CD (0.57) | SYKKDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL1856091 | 0.79 | SYK (0.52) | SYKKDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL1856094 | 0.78 | SYK (0.49) | SYKKDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL14900561 | 0.78 | SYK (0.53) | SYKKDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL1855610 | 0.77 | SYK (0.61) | SYKKDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL12424574 | 0.76 | SYK (0.61) | SYKKDM4EALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324022-A1 | SUBSTITUTED NAPHTHYRIDINES AND USE THEREOF AS MEDICINES | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010015520-A1 | SUBSTITUTED NAPHTHYRIDINES AND USE THEREOF AS MEDICINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |