Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856884 | 0.84 | FFAR1 (0.47) | FFAR1FFAR4HRH3KCNH2MMP2 | |
| SCHEMBL6725373 | 0.83 | FFAR1 (0.56) | FFAR1FFAR4HRH3KCNH2MMP2 | |
| SCHEMBL1851716 | 0.82 | FFAR1 (0.44) | FFAR1FFAR4KCNH2MMP2MMP12 | |
| SCHEMBL1853472 | 0.82 | FFAR1 (0.44) | FFAR1FFAR4KCNH2MMP2MMP12 | |
| SCHEMBL1852716 | 0.82 | FFAR1 (0.47) | ACHEFFAR1FFAR4SLC6A2SLC6A4 | |
| SCHEMBL1854389 | 0.82 | FFAR1 (0.47) | ACHEFFAR1FFAR4SLC6A2SLC6A4 | |
| SCHEMBL6783491 | 0.81 | FFAR1 (0.44) | FFAR1FFAR4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL1854088 | 0.79 | FFAR1 (0.42) | ACHEFFAR1FFAR4SLC6A2SLC6A4 | |
| SCHEMBL1849958 | 0.79 | FFAR1 (0.42) | ACHEFFAR1FFAR4SLC6A2SLC6A4 | |
| SCHEMBL1855383 | 0.78 | FFAR1 (0.42) | FFAR1FFAR4SLC6A2SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | disclosed |