Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | FAP | Q12884 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 7/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DAGLB | Q8NCG7 | 1/20 | 0.38 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18554262 | 1.00 | HRH3 (0.48) | HRH3KCNH2MMEMMEL1DPP4 | |
| SCHEMBL18554133 | 1.00 | HRH3 (0.48) | HRH3KCNH2MMEMMEL1DPP4 | |
| SCHEMBL18554134 | 1.00 | HRH3 (0.48) | HRH3KCNH2MMEMMEL1DPP4 | |
| SCHEMBL18576668 | 1.00 | HRH3 (0.48) | HRH3KCNH2MMEMMEL1DPP4 | |
| SCHEMBL18554259 | 1.00 | HRH3 (0.48) | HRH3KCNH2MMEMMEL1DPP4 | |
| SCHEMBL18576606 | 1.00 | HRH3 (0.48) | HRH3KCNH2MMEMMEL1DPP4 | |
| SCHEMBL18554136 | 0.83 | HRH3 (0.46) | HRH3KCNH2DPP4FAPDPP8 | |
| SCHEMBL18554135 | 0.83 | HRH3 (0.46) | HRH3KCNH2DPP4FAPDPP8 | |
| SCHEMBL18576607 | 0.83 | HRH3 (0.46) | HRH3KCNH2DPP4FAPDPP8 | |
| SCHEMBL18576667 | 0.83 | HRH3 (0.46) | HRH3KCNH2DPP4FAPDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017033128-A1 | BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS | NOVARTIS AG (CH) | 2017-03-02 | — | — | WO | disclosed |