Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 16/20 | 0.42 |
| ▸ | EED | O75530 | 13/20 | 0.42 |
| ▸ | RBBP4 | Q09028 | 13/20 | 0.42 |
| ▸ | SUZ12 | Q15022 | 13/20 | 0.42 |
| ▸ | AEBP2 | Q6ZN18 | 13/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18555890 | 1.00 | EZH2 (0.42) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18577991 | 0.91 | EZH2 (0.44) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18577990 | 0.91 | EZH2 (0.44) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16212957 | 0.80 | EZH2 (0.57) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16212959 | 0.80 | EZH2 (0.57) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16213269 | 0.79 | EED (0.57) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16213270 | 0.79 | EED (0.57) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18556072 | 0.78 | EZH2 (0.41) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16213153 | 0.77 | EED (0.57) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16212822 | 0.74 | EED (0.62) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341379-A1 | INHIBITORS OF EZH2 | Eli Lilly and Company (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017035060-A1 | INHIBITORS OF EZH2 | ELI LILLY AND COMPANY (US) | 2017-03-02 | — | — | WO | disclosed |