SCHEMBL1855722

SCHEMBL1855722

COc1cc(I)c(Cc2nc3c(N)nc(F)nc3[nH]2)cc1OC

nearest known ligand 0.45

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 9/20 0.45
HSP90AB1 P08238 9/20 0.45
ERBB2 P04626 3/20 0.37
MTNR1A P48039 1/20 0.34
MTNR1B P49286 1/20 0.34
F10 P00742 1/20 0.32
POLB P06746 1/20 0.32
HTR1A P08908 1/20 0.32
HTR2A P28223 1/20 0.32
HTR2C P28335 1/20 0.32
HTR2B P41595 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1857131 0.88 HSP90AA1 (0.45) HSP90AA1HSP90AB1ERBB2MTNR1AMTNR1B
SCHEMBL1858046 0.86 HSP90AA1 (0.50) HSP90AA1HSP90AB1ERBB2F10POLB
SCHEMBL14222613 0.82 HSP90AA1 (0.33) HSP90AA1HSP90AB1ERBB2
SCHEMBL1855723 0.81 HSP90AA1 (0.67) HSP90AA1HSP90AB1ERBB2MTNR1AMTNR1B
SCHEMBL30583198 0.81 HSP90AA1 (0.69) HSP90AA1HSP90AB1ERBB2
SCHEMBL4310551 0.81 HSP90AA1 (0.69) HSP90AA1HSP90AB1ERBB2
SCHEMBL1859066 0.80 POLB (0.53) HSP90AA1HSP90AB1POLB
SCHEMBL1856028 0.79 HSP90AA1 (0.50) HSP90AA1HSP90AB1ERBB2
SCHEMBL4849398 0.79 HSP90AA1 (0.48) HSP90AA1HSP90AB1
SCHEMBL1670297 0.78 HSP90AA1 (0.45) HSP90AA1HSP90AB1ERBB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210323965-A1 SMALL-MOLECULE HSP90 INHIBITORS SLOAN KETTERING INST CANCER RES (US) 2021-10-21 US disclosed
US-20200385389-A1 SMALL-MOLECULE HSP90 INHIBITORS SLOAN KETTERING INST CANCER RES (US) 2020-12-10 US disclosed
US-10676476-B2 Small-molecule HSP90 inhibitors SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2020-06-09 US disclosed
US-20190023708-A1 SMALL-MOLECULE HSP90 INHIBITORS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH 2019-01-24 US disclosed
US-10167285-B2 Small-molecule HSP90 inhibitors MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2019-01-01 US disclosed
US-10000494-B2 Small-molecule Hsp90 inhibitors SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2018-06-19 US disclosed
US-20170342073-A1 SMALL-MOLECULE HSP90 INHIBITORS MEMORIAL SLOAN KETTERING CANCER CENTER 2017-11-30 US disclosed
US-9701678-B2 Small-molecule HSP90 inhibitors MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2017-07-11 US disclosed
US-20160333014-A1 SMALL-MOLECULE HSP90 INHIBITORS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH 2016-11-17 US disclosed
US-9403828-B2 Small-molecule Hsp90 inhibitors SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2016-08-02 US disclosed
US-20140227183-A1 SMALL-MOLECULE HSP90 INHIBITORS MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2014-08-14 US disclosed
US-8703942-B2 Small-molecule Hsp90 inhibitors SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2014-04-22 US disclosed
US-20110312980-A1 Small-molecule Hsp90 Inhibitors SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2011-12-22 US disclosed
US-20110104054-A1 Small-Molecule HSP90 Inhibitors SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2011-05-05 US disclosed
US-7834181-B2 Small-molecule Hsp90 inhibitors SLAON-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2010-11-16 US disclosed
US-20080253965-A1 Small-Molecule Hsp90 Inhibitors SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2008-10-16 US disclosed
WO-2006084030-A2 SMALL-MOLECULE HSP90 INHIBITORS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2006-08-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200385389-A1 SMALL-MOLECULE HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P HSP90AA1 4/4885HSP90AB1 2/4885ERBB2 2127/4885
US-20170342073-A1 SMALL-MOLECULE HSP90 INHIBITORS HSP90B1, HSP90AB2P, HSP90AB1 HSP90AA1 4/4885HSP90AB1 3/4885ERBB2 711/4885
US-10000494-B2 Small-molecule Hsp90 inhibitors HSP90B1, HSP90AB1, HSP90AB2P HSP90AA1 4/4885HSP90AB1 2/4885ERBB2 2127/4885
US-20110104054-A1 Small-Molecule HSP90 Inhibitors HSP90AB2P, HSP90AB1, HSP90AA1 HSP90AA1 3/4885HSP90AB1 2/4885ERBB2 297/4885
US-20160333014-A1 SMALL-MOLECULE HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P HSP90AA1 4/4885HSP90AB1 2/4885ERBB2 2127/4885
US-20190023708-A1 SMALL-MOLECULE HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P HSP90AA1 4/4885HSP90AB1 2/4885ERBB2 2127/4885
US-10167285-B2 Small-molecule HSP90 inhibitors HSP90B1, HSP90AB2P, HSP90AB1 HSP90AA1 4/4885HSP90AB1 3/4885ERBB2 764/4885
US-20140227183-A1 SMALL-MOLECULE HSP90 INHIBITORS HSP90AB2P, HSP90AB1, HSP90B1 HSP90AA1 4/4885HSP90AB1 2/4885ERBB2 404/4885
US-20080253965-A1 Small-Molecule Hsp90 Inhibitors HSP90AB2P, HSP90AB1, HSP90AA1 HSP90AA1 3/4885HSP90AB1 2/4885ERBB2 355/4885
US-20210323965-A1 SMALL-MOLECULE HSP90 INHIBITORS HSP90B1, HSP90AB1, HSP90AB2P HSP90AA1 4/4885HSP90AB1 2/4885ERBB2 2127/4885
US-10676476-B2 Small-molecule HSP90 inhibitors HSP90B1, HSP90AB1, HSP90AB2P HSP90AA1 4/4885HSP90AB1 2/4885ERBB2 2127/4885
US-20110312980-A1 Small-molecule Hsp90 Inhibitors HSP90B1, HSP90AB1, HSP90AB2P HSP90AA1 4/4885HSP90AB1 2/4885ERBB2 2127/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.