Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | AOC1 | P19801 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24481241 | 0.92 | TSHR (0.44) | TSHRRPS6KA3HTTRAB9AKMT2A | |
| SCHEMBL269127 | 0.83 | RPS6KA3 (0.46) | TSHRRPS6KA3LIMK1ALOX5AOC1 | |
| SCHEMBL25493980 | 0.81 | TSHR (0.41) | TSHRRPS6KA3HTTRAB9AKMT2A | |
| SCHEMBL18672455 | 0.80 | TSHR (0.39) | TSHRHTTRAB9AKMT2ANPC1 | |
| SCHEMBL19250962 | 0.80 | TSHR (0.39) | TSHRHTTRAB9AKMT2ANPC1 | |
| SCHEMBL12512791 | 0.80 | TSHR (0.39) | TSHRRPS6KA3HTTRAB9AKMT2A | |
| SCHEMBL280624 | 0.80 | TSHR (0.39) | TSHRRPS6KA3HTTRAB9AKMT2A | |
| SCHEMBL13848825 | 0.80 | TSHR (0.39) | TSHRRPS6KA3HTTRAB9AKMT2A | |
| SCHEMBL23219772 | 0.78 | GAA (0.41) | TSHRRPS6KA3HTTRAB9AKMT2A | |
| SCHEMBL25493831 | 0.78 | TSHR (0.38) | TSHRHTTRAB9AKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580425-B2 | Pyrido[3,4-b] indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2017-02-28 | — | — | US | disclosed |