Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | LTK | P29376 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.54 |
| ▸ | PRKX | P51817 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18397650 | 0.80 | PLK4 (0.55) | HDAC1HDAC3PLK4CHEK1AURKA | |
| SCHEMBL24433138 | 0.79 | PLK4 (0.64) | HDAC1HDAC3TSHRPLK4CHEK1 | |
| SCHEMBL10244809 | 0.78 | HDAC1 (0.67) | HDAC1HDAC3TSHRHTTHPGD | |
| SCHEMBL22470277 | 0.78 | HDAC1 (0.56) | HDAC1HDAC3PLK4CHEK1AURKA | |
| SCHEMBL15786485 | 0.75 | PLK4 (0.59) | HDAC1HDAC3TSHRPLK4CHEK1 | |
| SCHEMBL29768842 | 0.75 | PLK4 (0.59) | HDAC1HDAC3TSHRPLK4CHEK1 | |
| SCHEMBL1937915 | 0.75 | HDAC3 (1.00) | HDAC1HDAC3 | |
| SCHEMBL19210845 | 0.75 | TSHR (1.00) | TSHRHTTHPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL24992498 | 0.75 | PLK4 (0.62) | HDAC1HDAC3TSHRPLK4CHEK1 | |
| SCHEMBL1093718 | 0.75 | TSHR (0.73) | HDAC1HDAC3TSHRHTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928473-B1 | REGIOSELECTIVE N-2 ARYLATION OF INDAZOLES | MERCK SHARP & DOHME (US) | 2017-06-28 | — | — | EP | disclosed |
| US-20170137403-A1 | REGIOSELECTIVE N-2 ARYLATION OF INDAZOLES | MERCK SHARP & DOHME CORP. (US) | 2017-05-18 | — | — | US | disclosed |
| US-9580407-B2 | Regioselective N-2 arylation of indazoles | MERCK SHARP & DOHME CORP. (US) | 2017-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137403-A1 | REGIOSELECTIVE N-2 ARYLATION OF INDAZOLES | PARP2, PARP1, PARP12 | HDAC1 413/4885HDAC3 642/4885TSHR 3698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.