Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17813269 | 0.78 | KMT2A (0.35) | NEK2LMNAMAPTKMT2AMEN1 | |
| SCHEMBL15804805 | 0.78 | KMT2A (0.35) | NEK2LMNAMAPTKMT2AMEN1 | |
| SCHEMBL15804820 | 0.78 | KMT2A (0.35) | NEK2LMNAMAPTKMT2AMEN1 | |
| SCHEMBL18845455 | 0.77 | — | — | |
| SCHEMBL23942213 | 0.77 | — | — | |
| SCHEMBL11102084 | 0.75 | EGFR (0.37) | ALDH1A1KDM4EPOLB | |
| SCHEMBL15156069 | 0.75 | EGFR (0.37) | ALDH1A1KDM4EPOLB | |
| SCHEMBL13857888 | 0.75 | EGFR (0.37) | ALDH1A1KDM4EPOLB | |
| SCHEMBL15710707 | 0.75 | NEK2 (0.38) | NEK2ALDH1A1KDM4ELMNAATM | |
| SCHEMBL24091686 | 0.74 | MEN1 (0.33) | NEK2MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580427-B2 | Kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-28 | — | — | US | disclosed |