Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3526305 | 0.88 | AHR (0.53) | SMN1; SMN2HPGDAHRNPC1RAB9A | |
| SCHEMBL24824320 | 0.87 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDAHRNPC1RAB9A | |
| SCHEMBL9966856 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL8431128 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2HPGDAHRNPC1RAB9A | |
| SCHEMBL14583969 | 0.81 | MAPT (0.61) | SMN1; SMN2AHRMAPTLMNAHTT | |
| SCHEMBL31633230 | 0.81 | MAPT (0.61) | SMN1; SMN2AHRMAPTLMNAHTT | |
| SCHEMBL8431565 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2HPGDAHRNPC1RAB9A | |
| SCHEMBL17206884 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDAHRNPC1RAB9A | |
| SCHEMBL38653375 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL15152237 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673890-B2 | 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-18 | — | — | US | disclosed |
| US-8673890-B2 | 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-18 | — | — | US | disclosed |
| US-8673890-B2 | 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-18 | — | — | US | disclosed |
| US-20110105490-A1 | 2,3-DIHYDRO-1H-ISOINDOL-1-IMINE DERIVATIVES USEFUL AS THROMBIN PAR-1 RECEPTOR ANTAGONIST | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | US | disclosed |
| US-20110105490-A1 | 2,3-DIHYDRO-1H-ISOINDOL-1-IMINE DERIVATIVES USEFUL AS THROMBIN PAR-1 RECEPTOR ANTAGONIST | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | US | disclosed |
| US-20110105490-A1 | 2,3-DIHYDRO-1H-ISOINDOL-1-IMINE DERIVATIVES USEFUL AS THROMBIN PAR-1 RECEPTOR ANTAGONIST | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | US | disclosed |
| EP-0470099-B1 | HAIR COLORANTS | HENKEL KGAA (DE) | 1993-11-03 | — | — | EP | disclosed |
| EP-0470099-A1 | HAIR COLORANTS. | HENKEL KGAA (DE) | 1992-02-12 | — | — | EP | disclosed |
| WO-1990012562-A1 | HAIR COLORANTS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1990-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105490-A1 | 2,3-DIHYDRO-1H-ISOINDOL-1-IMINE DERIVATIVES USEFUL AS THROMBIN PAR-1 RECEPTOR ANTAGONIST | F2R, F2RL1, F2RL3 | SMN1; SMN2 3382/4885HPGD 203/4885AHR 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.