⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11338382 | 0.85 | — | — | |
| SCHEMBL2890316 | 0.81 | — | — | |
| SCHEMBL11334048 | 0.75 | — | — | |
| SCHEMBL11346177 | 0.72 | — | — | |
| SCHEMBL11340425 | 0.69 | — | — | |
| SCHEMBL17452191 | 0.69 | CYP1A2 (0.34) | — | |
| SCHEMBL4445015 | 0.67 | — | — | |
| SCHEMBL258408 | 0.67 | — | — | |
| SCHEMBL19118411 | 0.67 | — | — | |
| SCHEMBL15202664 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673890-B2 | 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-18 | — | — | US | disclosed |
| US-20110105490-A1 | 2,3-DIHYDRO-1H-ISOINDOL-1-IMINE DERIVATIVES USEFUL AS THROMBIN PAR-1 RECEPTOR ANTAGONIST | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | US | disclosed |
| US-7851644-B2 | Heterocyclic metallocenes and polymerization catalysts | BASELL POLYOLEFINE GMBH (DE) | 2010-12-14 | — | — | US | disclosed |
| US-7705043-B2 | Substituted aminodicarboxylic acid derivatives having pharmaceutical properties | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-27 | — | — | US | disclosed |
| US-20090286945-A9 | Heterocyclic metallocenes and polymerization catalysts | EWEN JOHN A | 2009-11-19 | — | — | US | disclosed |
| US-20090163535-A1 | Substituted Heteroarylalkanoic Acids | THE INSTITUES FOR PHARMACEUTICAL DISCOVERY, INC. (US) | 2009-06-25 | — | — | US | disclosed |
| US-20090163535-A1 | Substituted Heteroarylalkanoic Acids | THE INSTITUES FOR PHARMACEUTICAL DISCOVERY, INC. (US) | 2009-06-25 | — | — | US | disclosed |
| US-20090163535-A1 | Substituted Heteroarylalkanoic Acids | THE INSTITUES FOR PHARMACEUTICAL DISCOVERY, INC. (US) | 2009-06-25 | — | — | US | disclosed |
| EP-1444228-B1 | SUBSTITUTED HETEROARYLALKANOIC ACIDS AND THEIR USE AS ALDOSE REDUCTASE INHIBITORS | INST FOR PHARM DISCOVERY INC (US) | 2008-05-21 | — | — | EP | disclosed |
| EP-1444228-B1 | SUBSTITUTED HETEROARYLALKANOIC ACIDS AND THEIR USE AS ALDOSE REDUCTASE INHIBITORS | INST FOR PHARM DISCOVERY INC (US) | 2008-05-21 | — | — | EP | disclosed |
| US-20030166668-A1 | Substituted heteroarylalkanoic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, INC. A CORPORATION OF THE STATE OF DELAWARE | 2003-09-04 | — | — | US | disclosed |
| EP-1327636-A2 | Heterocyclic metallocenes and polymerisation catalysts | Basell Polyolefine GmbH (DE) | 2003-07-16 | — | — | EP | disclosed |
| EP-0938491-B1 | HETEROCYCLIC METALLOCENES AND POLYMERIZATION CATALYSTS | BASELL POLYOLEFINE GMBH (DE) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002070510-A2 | AMINO DICARBOXYLIC ACID DERIVATIVES WITH PHARMACEUTICAL PROPERTIES | BAYER AKTIENGESELLSCHAFT (DE) | 2002-09-12 | — | — | WO | disclosed |
| US-5380742-A | Antagonists to a2-type adrenergic receptors | SYNTHELABO (FR) | 1995-01-10 | — | — | US | disclosed |
| EP-0414076-B1 | Cyclic substituted (quinoline-2-yl-methoxy)phenylacetic acid derivatives | BAYER AG (DE) | 1994-10-12 | — | — | EP | disclosed |
| EP-0599697-A1 | Pyrrole derivatives, their preparation and application in therapy | SYNTHELABO (FR) | 1994-06-01 | — | — | EP | disclosed |
| US-5192771-A | Lipoxygenase inhibitors as antiinflammatory agents | BAYER AKTIENGESELLSCHAFT (DE) | 1993-03-09 | — | — | US | disclosed |
| EP-0414076-A1 | Cyclic substituted (quinoline-2-yl-methoxy)phenylacetic acid derivatives | BAYER AG (DE) | 1991-02-27 | — | — | EP | disclosed |
| US-4152335-A | CROWN COMPOUNDS, NONHYGROSCOPIC | SHELL OIL COMPANY (US) | 1979-05-01 | — | — | US | disclosed |