Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18567410 | 0.92 | BACE1 (0.51) | BACE1BACE2 | |
| SCHEMBL18567769 | 0.90 | BACE1 (0.51) | BACE1BACE2 | |
| SCHEMBL18567766 | 0.90 | BACE1 (0.53) | BACE1BACE2 | |
| SCHEMBL18567411 | 0.89 | BACE1 (0.54) | BACE1BACE2 | |
| SCHEMBL18567775 | 0.86 | BACE1 (0.54) | BACE1BACE2 | |
| SCHEMBL15693514 | 0.83 | BACE1 (0.65) | BACE1BACE2 | |
| SCHEMBL17127261 | 0.79 | BACE1 (0.66) | BACE1BACE2 | |
| SCHEMBL20056278 | 0.77 | BACE1 (0.51) | BACE1BACE2 | |
| SCHEMBL15693515 | 0.75 | BACE1 (0.64) | BACE1BACE2 | |
| SCHEMBL15693516 | 0.74 | BACE1 (0.55) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697210-B1 | 5-SUBSTITUTED IMINOTHIAZINES AND THEIR MONO-AND DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2017-03-01 | — | — | EP | disclosed |